John W Eikelboom Selected Research

Antidotes

1/2023	Final Study Report of Andexanet Alfa for Major Bleeding With Factor Xa Inhibitors.
1/2021	Hemostatic Efficacy and Anti-FXa (Factor Xa) Reversal With Andexanet Alfa in Intracranial Hemorrhage: ANNEXA-4 Substudy.
4/2016	Effectiveness and outcome of management strategies for dabigatran- or warfarin-related major bleeding events.
4/2014	Recent advances in antidotes for direct oral anticoagulants: their arrival is imminent.
1/2014	Betrixaban (PRT054021): pharmacology, dose selection and clinical studies.
8/2013	Novel oral anticoagulants for atrial fibrillation.

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John W Eikelboom Research Topics

Disease

172	Hemorrhage 03/2024 - 01/2002
141	Stroke (Strokes) 01/2024 - 04/2002
108	Atrial Fibrillation 01/2024 - 02/2004
57	Myocardial Infarction 01/2024 - 04/2002
47	Thrombosis (Thrombus) 01/2024 - 09/2003
42	Ischemic Stroke 01/2023 - 03/2003
39	Venous Thromboembolism 01/2024 - 07/2002
35	Peripheral Arterial Disease 05/2024 - 08/2004
33	Acute Coronary Syndrome 01/2021 - 01/2002
31	Cardiovascular Diseases (Cardiovascular Disease) 03/2024 - 01/2007
27	Coronary Artery Disease (Coronary Atherosclerosis) 07/2023 - 03/2010
21	Embolism (Embolus) 04/2021 - 05/2005
14	Venous Thrombosis (Deep-Vein Thrombosis) 01/2024 - 07/2002
13	Vascular Diseases (Vascular Disease) 11/2022 - 01/2004
12	ST Elevation Myocardial Infarction 01/2024 - 01/2004
12	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2023 - 01/2012
12	Thromboembolism 02/2022 - 09/2010
10	Coronary Disease (Coronary Heart Disease) 01/2023 - 03/2004
10	Pulmonary Embolism 12/2022 - 07/2002
10	Atherosclerosis 01/2022 - 01/2009
9	Heart Failure 11/2023 - 05/2012
9	Inflammation (Inflammations) 01/2023 - 01/2009
8	COVID-19 11/2023 - 01/2020
8	Neoplasms (Cancer) 01/2022 - 11/2002
7	Embolic Stroke 06/2022 - 03/2011
7	Ischemia 01/2021 - 11/2011
6	Transient Ischemic Attack 11/2016 - 05/2008
5	Chronic Kidney Failure (Chronic Renal Failure) 01/2024 - 10/2012
5	Chronic Renal Insufficiency 01/2022 - 08/2012
5	Unstable Angina 01/2018 - 01/2005
4	Body Weight (Weight, Body) 01/2024 - 11/2009
4	Cognitive Dysfunction 10/2020 - 09/2008
4	Atherosclerotic Plaque (Atheroma) 01/2014 - 10/2006
4	Thrombocytopenia (Thrombopenia) 09/2012 - 10/2002
3	Infarction (Infarctions) 01/2024 - 08/2016
3	Infections 11/2023 - 01/2019
3	Disease Progression 01/2023 - 12/2022
3	Vascular Calcification 11/2021 - 11/2012
3	Brain Infarction 10/2020 - 08/2016
3	Diabetes Mellitus 01/2020 - 01/2019
3	Renal Insufficiency (Renal Failure) 01/2018 - 10/2002

Drug/Important Bio-Agent (IBA)

105	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 11/2023 - 04/2002
99	AnticoagulantsIBA 01/2024 - 07/2002
73	Warfarin (Coumadin)FDA LinkGeneric 01/2024 - 07/2003
61	RivaroxabanIBA 05/2024 - 01/2011
46	Dabigatran FDA Link 06/2022 - 04/2010
34	apixabanIBA 02/2024 - 03/2010
33	Vitamin K FDA Link 01/2024 - 10/2003
32	Clopidogrel (Plavix)FDA Link 01/2022 - 06/2003
20	Colchicine FDA LinkGeneric 01/2024 - 01/2012
19	Heparin (Liquaemin)FDA LinkGeneric 07/2020 - 01/2002
17	Biomarkers (Surrogate Marker)IBA 11/2023 - 06/2016
14	omega-Chloroacetophenone (Mace)IBA 03/2024 - 01/2018
11	Factor Xa InhibitorsIBA 01/2023 - 11/2008
11	CreatinineIBA 01/2023 - 05/2006
9	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 10/2023 - 06/2003
9	Enoxaparin (Lovenox)FDA LinkGeneric 01/2023 - 05/2006
9	Factor Xa (Coagulation Factor Xa)IBA 01/2021 - 01/2009
9	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 01/2019 - 02/2004
9	HomocysteineIBA 09/2013 - 09/2004
9	Folic Acid (Vitamin M)FDA LinkGeneric 09/2013 - 08/2004
8	Vitamin B Complex (B Vitamins)IBA 09/2013 - 06/2008
7	Fibrinolytic Agents (Antithrombotic Agents)IBA 03/2024 - 07/2008
7	Hemostatics (Antihemorrhagics)IBA 01/2023 - 02/2013
7	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2023 - 07/2016
7	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 09/2013 - 02/2006
6	AntithrombinsIBA 01/2023 - 01/2002
6	AntidotesIBA 01/2023 - 08/2013
6	PRT064445IBA 01/2023 - 01/2016
6	edoxabanIBA 01/2023 - 05/2014
6	Thrombin FDA Link 01/2020 - 03/2010
6	VitaminsIBA 09/2013 - 09/2004
6	Vitamin B 6IBA 09/2013 - 06/2008
6	Fondaparinux (Arixtra)FDA Link 12/2010 - 10/2007
5	N(4)-oleylcytosine arabinosideIBA 01/2024 - 07/2013
5	pro-brain natriuretic peptide (1-76)IBA 01/2023 - 11/2016
5	betrixabanIBA 01/2023 - 01/2014
5	Troponin T (Troponin T1)IBA 01/2022 - 06/2016
4	Hemoglobins (Hemoglobin)IBA 01/2022 - 08/2017
4	Growth Differentiation Factor 15IBA 11/2021 - 08/2017
4	bivalirudin (Angiomax)FDA Link 12/2015 - 01/2002
4	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 03/2014 - 10/2008
4	TabletsIBA 09/2013 - 06/2012
4	HirudinsIBA 09/2012 - 01/2002
3	Proton Pump InhibitorsIBA 03/2024 - 01/2017
3	TicagrelorIBA 11/2023 - 07/2014
3	Cytochrome P-450 CYP2C19IBA 01/2022 - 10/2010
3	plasma protein Z (protein Z)IBA 05/2020 - 10/2003
3	TroponinIBA 01/2020 - 01/2009
3	CholesterolIBA 01/2020 - 01/2014
3	fibrin fragment D (D-dimer)IBA 11/2017 - 12/2003
3	C-Reactive ProteinIBA 11/2016 - 03/2003

Therapy/Procedure

146	Therapeutics 03/2024 - 07/2003
24	Percutaneous Coronary Intervention 01/2024 - 01/2002
15	Stents 01/2021 - 05/2010
10	Secondary Prevention 01/2021 - 05/2008
7	Surgical Amputation (Amputations) 01/2021 - 08/2004
4	Drug Tapering 01/2022 - 01/2021
4	Thrombolytic Therapy 09/2009 - 01/2004
3	Polypharmacy 11/2022 - 01/2019